Encapsulated rna polynucleotides and methods of use
OwnerLorena LERNER, Edward M. KENNEDY +2inventors
InventorsLorena LERNER, Edward M. KENNEDY, Mitchell H. FINER, Christophe QUÉVA
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Abstract
The present disclosure relates to recombinant RNA molecules encoding an oncolytic virus. The present disclosure further relates to the encapsulation of the recombinant RNA molecules and the use of the recombinant RNA molecules and/or particles for the treatment and prevention of cancer.
Claims168
A lipid nanoparticle (LNP) comprising a synthetic RNA viral genome encoding an oncolytic virus.
A recombinant RNA molecule comprising a synthetic RNA viral genome encoding an oncolytic virus.
The recombinant RNA molecule of claim 141, wherein the nucleic acid vector is a replicon.
Dependencies are inferred from the claim text.