Automated microdissection instrument
AssigneeLife Technologies Corporation
InventorsThomas M. Baer, Michael G. Youngquist, Brian W. Donovan, Alan E. Wessel, Norbert H. Leclerc, Michael A. Smith, Craig S. Barker, George M. Dawson
Life of this patent
Estimating the term…
Abstract
Systems and methods for automated laser microdissection are disclosed including automatic slide detection, position detection of cutting and capture lasers, focus optimization for cutting and capture lasers, energy and duration optimization for cutting and capture lasers, inspection and second phase capture and/or ablation in a quality control station and tracking information for linking substrate carrier or output microdissected regions with input sample or slide.
Claims13
A method for processing a biological sample using a laser microdissection instrument, comprising:
- calibrating a capture laser to determine an optimal setting for wetting a transfer film mounted on a cap;
- bringing the transfer film into juxtaposition with a targeted portion of biological material on a substrate;
- directing the capture laser to fire at the targeted portion of biological material to form an area of adhesion between a wetted portion of the transfer film and the targeted portion of biological material;
- and
- moving the cap away from the substrate, thereby removing the targeted portion of biological material with the cap.
Dependencies are inferred from the claim text.