Method for Producing Virus-Infected Cell Line and Animal Model
AssigneesIndustry-Academic Cooperation Foundation, Yonsei University, University Industry Foundation, Yonsei University Wonju Campus
InventorsHong Jai Lee, Soo Ki Kim, Jae Seung Moon, Bo Young Shin, Jin Su Shin, Sang Kyou Lee
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Abstract
Disclosed herein are methods for producing virus-infected cell lines or animal models, wherein an enveloped virus including a lipid bilayer is mixed with a bile acid or a bile acid derivative, which allows the lipid bilayer to be replaced with a lipid bilayer derived from a target animal. Also disclosed herein are the virus-infected cell lines or animal models so produced and methods of screening a therapeutic candidate for a viral disease using the same.
Claims17
1-27. (canceled)
A method for producing a virus-infected cell line, the method comprising:
- (1) mixing an enveloped virus including a lipid bilayer with a bile acid or a bile acid derivative;
- and
- (2) adding the virus from (1) to a culture medium of a cell line, thereby producing a virus-infected cell line.
A method for producing a virus-infected animal model, the method comprising:
- (1) replacing a lipid bilayer of an enveloped virus with a lipid bilayer derived from a target animal;
- and
- (2) injecting the virus for which the lipid bilayer replacement has been achieved into the target animal, thereby producing a virus-infected animal model.
Dependencies are inferred from the claim text.