US 2022/0112273 A1Published application

DNA Antibody Constructs And Method Of Using Same

AssigneesThe Trustees of the University of Pennsylvania, Inovio Pharmaceuticals, Inc.

InventorsDavid Weiner, Karuppiah Muthumani, Seleeke Flingai, Niranjan Sardesai

Life of this patent

Estimating the term…

Abstract

Disclosed herein is a composition including a recombinant nucleic acid sequence that encodes an antibody. Also disclosed herein is a method of generating a synthetic antibody in a subject by administering the composition to the subject. The disclosure also provides a method of preventing and/or treating disease in a subject using said composition and method of generation.

Claims26

Dependent claims

A nucleic acid molecule encoding a synthetic antibody comprising one or more nucleic acid sequences selected from the group consisting of:

(a)
(b) a nucleic acid sequence that is at least 80% homologous to a nucleotide sequence that encodes SEQ ID NO:
67, a fragment of a nucleotide sequence that encodes SEQ ID NO:
67, a nucleic acid sequence that is at least 80% homologous to a fragment of a nucleotide sequence that encodes SEQ ID NO:
67;
(c) a nucleic acid sequence that is at least 80% homologous to a nucleotide sequence that encodes SEQ ID NO:
69, a fragment of a nucleotide sequence that encodes SEQ ID NO:
69, a nucleic acid sequence that is at least 80% homologous to a fragment of a nucleotide sequence that encodes SEQ ID NO:
69;
(d) a nucleic acid sequence that is at least 80% homologous to a nucleotide sequence that encodes SEQ ID NO:
71, a fragment of a nucleotide sequence that encodes SEQ ID NO:
71, a nucleic acid sequence that is at least 80% homologous to a fragment of a nucleotide sequence that encodes SEQ ID NO:
71;
(e) a nucleic acid sequence that is at least 80% homologous to a nucleotide sequence that encodes SEQ ID NO:
73, a fragment of a nucleotide sequence that encodes SEQ ID NO:
73, a nucleic acid sequence that is at least 80% homologous to a fragment of a nucleotide sequence that encodes SEQ ID NO:
73;
(f) a nucleic acid sequence that is at least 80% homologous to a nucleotide sequence that encodes SEQ ID NO:
75, a fragment of a nucleotide sequence that encodes SEQ ID NO:
75, a nucleic acid sequence that is at least 80% homologous to a fragment of a nucleotide sequence that encodes SEQ ID NO:
75;
(g) a nucleic acid sequence that is at least 80% homologous to a nucleotide sequence that encodes SEQ ID NO:
77, a fragment of a nucleotide sequence that encodes SEQ ID NO:
77, a nucleic acid sequence that is at least 80% homologous to a fragment of a nucleotide sequence that encodes SEQ ID NO:
77;
and
(h)
(i)
(j) a nucleic acid sequence that is at least 80% homologous to a nucleotide sequence that encodes SEQ ID NO:
65, a fragment of a nucleotide sequence that encodes SEQ ID NO:
65, a nucleic acid sequence that is at least 80% homologous to a fragment of a nucleotide sequence that encodes SEQ ID NO:
65.

29 more elements

A nucleic acid molecule encoding a synthetic antibody comprising one or more nucleic acid sequences selected from the group consisting of:

(a)
(b) an amino acid sequence that is at least 80% homologous to SEQ ID NO:
68, a fragment of an amino acid sequence that encodes SEQ ID NO:
68, an amino acid sequence that is at least 80% homologous to a fragment of an amino acid sequence that encodes SEQ ID NO:
68;
(c) an amino acid sequence that is at least 80% homologous to SEQ ID NO:
70, a fragment of an amino acid sequence that encodes SEQ ID NO:
70, an amino acid sequence that is at least 80% homologous to a fragment of an amino acid sequence that encodes SEQ ID NO:
70;
(d) an amino acid sequence that is at least 80% homologous to SEQ ID NO:
72, a fragment of an amino acid sequence that encodes SEQ ID NO:
72, an amino acid sequence that is at least 80% homologous to a fragment of an amino acid sequence that encodes SEQ ID NO:
72;
(e) an amino acid sequence that is at least 80% homologous to SEQ ID NO:
74, a fragment of an amino acid sequence that encodes SEQ ID NO:
74, an amino acid sequence that is at least 80% homologous to a fragment of an amino acid sequence that encodes SEQ ID NO:
74;
(f) an amino acid sequence that is at least 80% homologous to SEQ ID NO:
76, a fragment of an amino acid sequence that encodes SEQ ID NO:
76, an amino acid sequence that is at least 80% homologous to a fragment of an amino acid sequence that encodes SEQ ID NO:
76;
(g) an amino acid sequence that is at least 80% homologous to SEQ ID NO:
78, a fragment of an amino acid sequence that encodes SEQ ID NO:
78, an amino acid sequence that is at least 80% homologous to a fragment of an amino acid sequence that encodes SEQ ID NO:
78;
and
(h)
(i)
(j) an amino acid sequence that is at least 80% homologous to SEQ ID NO:
66, a fragment of an amino acid sequence that encodes SEQ ID NO:
66, an amino acid sequence that is at least 80% homologous to a fragment of an amino acid sequence that encodes SEQ ID NO:
66.

29 more elements

Dependencies are inferred from the claim text.

Facts

Application: 17/554,642Filed 17 Dec 2021
Priority: 13 Dec 2013
Published: 14 Apr 2022
Term ends: Not estimatedThe source records don’t support an estimate.

Classification35 codes

C07K 16/116
RNA viruses: togaviridae ; Matonaviridae ; Flaviviridae
A61K 31/7088
Carbohydrates; Sugars; Derivatives thereof: compounds having three or more nucleosides or nucleotides
A61K 39/12
Medicinal preparations containing antigens or antibodies: viral antigens
A61K 39/21
Viral antigens: retroviridae, e.g. equine infectious anemia virus

Family

Application15/103,970Continuation · filed 13 Jun 2016
Application16/142,457Continuation · filed 26 Sep 2018
Application17/554,642Continuation
US 10,087,240 B2Related patent
US 11,208,470 B2Related patent
US 2016/0311891 A1Published application
US 2019/0085058 A1Published application
US 2022/0112273 A1This patent

From the US filing history. Foreign family members aren’t listed.

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Abstract

A nucleic acid molecule encoding a synthetic antibody comprising one or more nucleic acid sequences selected from the group consisting of:

(a)
(b) a nucleic acid sequence that is at least 80% homologous to a nucleotide sequence that encodes SEQ ID NO:
67, a fragment of a nucleotide sequence that encodes SEQ ID NO:
67, a nucleic acid sequence that is at least 80% homologous to a fragment of a nucleotide sequence that encodes SEQ ID NO:
67;
(c) a nucleic acid sequence that is at least 80% homologous to a nucleotide sequence that encodes SEQ ID NO:
69, a fragment of a nucleotide sequence that encodes SEQ ID NO:
69, a nucleic acid sequence that is at least 80% homologous to a fragment of a nucleotide sequence that encodes SEQ ID NO:
69;
(d) a nucleic acid sequence that is at least 80% homologous to a nucleotide sequence that encodes SEQ ID NO:
71, a fragment of a nucleotide sequence that encodes SEQ ID NO:
71, a nucleic acid sequence that is at least 80% homologous to a fragment of a nucleotide sequence that encodes SEQ ID NO:
71;
(e) a nucleic acid sequence that is at least 80% homologous to a nucleotide sequence that encodes SEQ ID NO:
73, a fragment of a nucleotide sequence that encodes SEQ ID NO:
73, a nucleic acid sequence that is at least 80% homologous to a fragment of a nucleotide sequence that encodes SEQ ID NO:
73;
(f) a nucleic acid sequence that is at least 80% homologous to a nucleotide sequence that encodes SEQ ID NO:
75, a fragment of a nucleotide sequence that encodes SEQ ID NO:
75, a nucleic acid sequence that is at least 80% homologous to a fragment of a nucleotide sequence that encodes SEQ ID NO:
75;
(g) a nucleic acid sequence that is at least 80% homologous to a nucleotide sequence that encodes SEQ ID NO:
77, a fragment of a nucleotide sequence that encodes SEQ ID NO:
77, a nucleic acid sequence that is at least 80% homologous to a fragment of a nucleotide sequence that encodes SEQ ID NO:
77;
and
(h)
(i)
(j) a nucleic acid sequence that is at least 80% homologous to a nucleotide sequence that encodes SEQ ID NO:
65, a fragment of a nucleotide sequence that encodes SEQ ID NO:
65, a nucleic acid sequence that is at least 80% homologous to a fragment of a nucleotide sequence that encodes SEQ ID NO:
65.

29 more elements

Facts

Application

17/554,642Filed 17 Dec 2021

Priority

13 Dec 2013

Published

14 Apr 2022

Term ends

Not estimatedThe source records don’t support an estimate.

Classification35 codes

C07K 16/116
RNA viruses: togaviridae ; Matonaviridae ; Flaviviridae
A61K 31/7088
Carbohydrates; Sugars; Derivatives thereof: compounds having three or more nucleosides or nucleotides
A61K 39/12
Medicinal preparations containing antigens or antibodies: viral antigens
A61K 39/21
Viral antigens: retroviridae, e.g. equine infectious anemia virus

Family

Application15/103,970Continuation · filed 13 Jun 2016

Application16/142,457Continuation · filed 26 Sep 2018

Application17/554,642Continuation

US 10,087,240 B2Related patent

US 11,208,470 B2Related patent

US 2016/0311891 A1Published application

US 2019/0085058 A1Published application

US 2022/0112273 A1This patent

From the US filing history. Foreign family members aren’t listed.