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US 2022/0112245 A2Published application
Chimpanzee adenovirus constructs with lyssavirus antigens
AssigneeGlaxosmithkline Biologicals SA
InventorsVirginia AMMENDOLA, Stefano COLLOCA, Alessandra VITELLI, Benjamin WIZEL
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Abstract
The invention provides adenoviral vectors comprising transgenes encoding Lyssaviral antigens. The vectors can be used to produce vaccines for the prophylaxis, amelioration and treatment of diseases caused by Lyssaviral diseases, e.g., rabies.
Claims21
1-80. (canceled)
A recombinant nonhuman simian adenovirus comprising
- (a) a polynucleotide which encodes a polypeptide having the amino acid sequence according to SEQ ID NO:
- 1 or a functional derivative of a polynucleotide which encodes a polypeptide having the amino acid sequence according to SEQ ID NO:
- 1 wherein the functional derivative encodes an amino acid sequence which is at least 80% identical over its entire length to the amino acid sequence of SEQ ID NO:
- 1;
- (b) a polynucleotide which encodes a polypeptide having the amino acid sequence according to SEQ ID NO:
- 3 or a functional derivative of a polynucleotide which encodes a polypeptide having the amino acid sequence according to SEQ ID NO:
- 3 wherein the functional derivative encodes an amino acid sequence which is at least 80% identical over its entire length to the amino acid sequence of SEQ ID NO:
- 3;
- and
- (c) a polynucleotide which encodes a polypeptide having the amino acid sequence according to SEQ ID NO:
- 5 or a functional derivative of a polynucleotide which encodes a polypeptide having the amino acid sequence according to SEQ ID NO:
- 5 wherein the functional derivative encodes an amino acid sequence which is at least 80% identical over its entire length to the amino acid sequence of SEQ ID NO:
- 5;
- wherein the adenovirus comprises a nucleic acid sequence encoding a Lyssavirus antigen, wherein the nucleic acid sequence is operatively linked to one or more sequences which direct expression of the Lyssavirus antigen in a host cell.
11 more elements
Dependencies are inferred from the claim text.