Method for producing peptide compound, protective group-forming reagent, and condensed polycyclic compound
AssigneeFUJIFILM Corporation
InventorsYosuke YAMAMOTO, Makoto TAKAHASHI
Life of this patent
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Abstract
Provided are a method for producing a peptide compound including a step of using a compound represented by Formula (1); a protective group-forming reagent including the compound; and the compound. At least one of R1 to R8 or Y2 has RA, RA represents an aliphatic hydrocarbon group or an organic group having an aliphatic hydrocarbon group, and the number of carbon atoms in at least one aliphatic hydrocarbon group is 12 or more. However, RA does not have a silyl group and a hydrocarbon group having a silyloxy structure.
Claims17
A method for producing a peptide compound, comprising:
- a step of using a compound represented by Formula (1),
- in Formula (1),
- Y1 represents —OR17, —NHR18, —SH, or a halogen atom, where R17 represents a hydrogen atom, an active ester-type carbonyl group, or an active ester-type sulfonyl group, and R18 represents a hydrogen atom, an alkyl group, an arylalkyl group, a heteroarylalkyl group, or a 9-fluorenylmethoxycarbonyl group,
- Y2 represents —N(R110)—, —O—, —S—, —CR100═CR101—, —CR102R103—CR104R105—, or —CR106R107—, where R110 represents RA or an alkyl group, and R100 to R107 each independently represent a hydrogen atom or an alkyl group,
- R1 to R8 each independently represent RA, a hydrogen atom, a halogen atom, an alkyl group, or an alkoxy group,
- at least one of R1 to R8 or Y2 has RA,
- RA represents an aliphatic hydrocarbon group or an organic group having an aliphatic hydrocarbon group, and
- the number of carbon atoms in at least one aliphatic hydrocarbon group is 12 or more,
- provided that, RA does not have a silyl group and a hydrocarbon group having a silyloxy structure.
A protective group-forming reagent comprising:
- a compound represented by Formula (1),
- in Formula (1),
- Y1 represents —OR17, —NHR8, —SH, or a halogen atom, where R17 represents a hydrogen atom, an active ester-type carbonyl group, or an active ester-type sulfonyl group, and R18 represents a hydrogen atom, an alkyl group, an arylalkyl group, a heteroarylalkyl group, or a 9-fluorenylmethoxycarbonyl group,
- Y2 represents —N(R110)—, —O—, —S—, —CR100═CR101—, —CR102R103—CR104R105—, or —CR106R107—, where R110 represents RA or an alkyl group, and R100 to R107 each independently represent a hydrogen atom or an alkyl group,
- R1 to R8 each independently represent RA, a hydrogen atom, a halogen atom, an alkyl group, or an alkoxy group,
- at least one of R1 to R8 or Y2 has RA,
- RA represents an aliphatic hydrocarbon group or an organic group having an aliphatic hydrocarbon group, and
- the number of carbon atoms in at least one aliphatic hydrocarbon group is 12 or more,
- provided that, RA does not have a silyl group and a hydrocarbon group having a silyloxy structure.
A condensed polycyclic compound represented by Formula (1a),
- in Formula (1a),
- Ya1 represents —ORa17, —NHRa18, —SH, or a halogen atom, where Ra17 represents a hydrogen atom, an active ester-type carbonyl group, or an active ester-type sulfonyl group, and Ra18 represents a hydrogen atom, a linear or branched alkyl group having 10 or less carbon atoms, an arylalkyl group, a heteroarylalkyl group, or a 9-fluorenylmethoxycarbonyl group,
- Ya2 represents —N(R110)—, —O—, —S—, —CRa100═CRa101—, —CRa102Ra103—CRa104Ra105—, or —CRa106Ra107—, where R110 represents RA or an alkyl group, and Ra100 to Ra107 each independently represent a hydrogen atom or an alkyl group,
- Ra1 to Ra8 each independently represent RA, a hydrogen atom, a halogen atom, an alkyl group having 1 to 4 carbon atoms, or an alkoxy group having 1 to 4 carbon atoms,
- at least one of Ra2, . . . , or Ra7 has RA,
- RA represents an aliphatic hydrocarbon group or an organic group having an aliphatic hydrocarbon group, and
- the number of carbon atoms in at least one aliphatic hydrocarbon group is 12 or more,
- provided that, RA does not have a silyl group and a hydrocarbon group having a silyloxy structure.
Dependencies are inferred from the claim text.