Bone regeneration material
AssigneeWishbone
InventorsEric ROMPEN, Geoffrey LECLOUX, France LAMBERT, Emilie DORY
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Abstract
The present invention relates to a bone regeneration material comprising: a solid first phase of hydroxyapatite of natural origin which is macroporous, having pores of diameters greater than or equal to 50 μm, this phase of hydroxyapatite is a crystalline solid phase of hydroxyapatite, whose crystals have a size comprised between 20 and 120 nm, and this solid phase of hydroxyapatite has a specific surface area comprised between 8 and 20 m2/g, the method of production and a method of bone repair based on this bone regeneration material.
Claims25
A bone regeneration material consisting essentially of a solid phase of hydroxyapatite of natural origin which is macroporous having pores of diameters greater than or equal to 50 μm, wherein said phase of hydroxyapatite is a crystalline solid phase of hydroxyapatite, wherein the crystals have a size comprised between 20 and 120 nm, and said solid phase of hydroxyapatite has a specific surface area comprised between 8 and 20 m2/g.
A method to produce a bone regeneration material comprising the following steps:
- contacting a bone material of natural origin comprising hydroxyapatite and organic substances with an extraction aqueous solution at a temperature between 150° C. and 300° C. and at a pressure comprised between 1500 kPa and 3500 kPa so as to obtain a first liquid phase comprising said organic substances and potential impurities extracted from the said bone material, and a second phase of solid hydroxyapatite,
- separating the said liquid phase from the said solid hydroxyapatite phase,
- sintering the said separated solid hydroxyapatite phase at a temperature comprised between 800° C. and 1200° C.,
- optionally rinsing the said sintered hydroxyapatite,
- wherein the said sintered hydroxyapatite phase forms the said bone regeneration material.
Dependencies are inferred from the claim text.