Compound decreasing the concentration of 2-hydroxy-glutarate
AssigneesUniversität Heidelberg, Christian-Albrechts-Universität zu Kiel
InventorsOliver MÜLLER, Hugo KATUS, Norbert FREY, Lin DING, Andreas JUNGMANN, Anca REMES, Philipp SCHATZ, Beate KAMLAGE, Philipp TERNES
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Abstract
The present invention relates to a compound decreasing the concentration of 2-hydroxy-glutarate (2HG) in a subject for use in treating, preventing, and/or preventing progression of cardiac remodeling, in particular cardiomyopathy and/or heart failure and to viral particles, compositions, uses and methods related thereto.
Claims20
1-26. (canceled)
A method for treating, preventing, and/or preventing progression of cardiac remodeling, in particular cardiomyopathy and/or heart failure in a subject, comprising:
- (a) contacting the subject with a compound that decreases the concentration of 2-hydroxy-glutarate (2HG);
- and
- (b) thereby treating, preventing, and/or preventing progression of cardiac remodeling.
A viral particle comprising a polynucleotide comprising an expressible sequence encoding a 2HGDH, preferably an L2HGDH.
A kit comprising:
- (a) a polynucleotide comprising an expressible sequence encoding a 2HGDH, preferably an L2HGDH, and at least one viral packaging signal, and
- (b) a corresponding packaging helper polynucleotide and/or a corresponding packaging cell line.
Dependencies are inferred from the claim text.