Primed muscle progenitor cells and uses thereof
AssigneePurdue Research Foundation
InventorStacey L Halum
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Abstract
This invention relates to a method for repairing and reconstructing a damaged or non-functional muscle, in particular to a method and a tool kit using in vitro primed motor endplate-expressing muscle progenitor cells (MPCs) to promote innervation of the damaged or non-functional muscle using an agent without any genetic manipulation. This method is particularly useful for repairing or reconstructing damaged or non-functional head and neck muscles, and urinary detrusor bladder muscle.
Claims20
A tool kit of cell therapy comprising a plurality of primed motor endplate-expressing muscle progenitor cells (MPCs) obtained from a patient with a damaged or non-functioning muscle, wherein the primed MPCs are introduced to and enhance innervations of the damaged or non-functioning muscle of the patient.
A method of priming motor endplate-expressing muscle progenitor cells (MPCs) for a cell therapy for treating a patient with a damaged or non-functioning muscle, comprising:
- a) acquiring a plurality of motor endplate-expressing muscle progenitor cells (MPCs) from a patient with a damaged or non-functioning muscle, and
- b) priming the MPCs in vitro in the presence of an agent selected from the group consisting of acetylcholine, neuregulin, agrin, and a combination thereof.
Dependencies are inferred from the claim text.