US 2022/0110895 A1 · BETA-HYDROXYBUTYRATE MIXED SALT COMPOSITIONS AND METHODS OF USE

Abstract

Ketogenic compositions including a plurality of beta-hydroxybutyrate (BHB) salts are formulated to induce or sustain ketosis in a subject to which the ketogenic compositions are administered. The BHB mixed salt is formulated to provide a biologically balanced set of cationic electrolytes and avoid detrimental health effects associated with imbalanced electrolyte ratios. A ketogenic composition includes BHB salts selected from sodium, potassium, calcium, and magnesium salts. The BHB composition may also include transition metal cations (e.g., zinc or iron), one or more BHB-amino acid salts, one or more ketone precursors, supplements, or other compounds that cause a rise in blood ketone levels without adding more electrolytes to the bloodstream, a short-, medium-, or long-chain fatty acid source, vitamins, minerals, flavorants, or other excipients.

Claims20

Dependent claims

A composition for increasing ketone level in a subject, comprising:

a plurality of beta-hydroxybutyrate salts comprised of:
at least one beta-hydroxybutyrate salt selected from:
calcium beta-hydroxybutyrate;
and
magnesium beta-hydroxybutyrate;
and
at least one other beta-hydroxybutyrate salt selected from:
sodium beta-hydroxybutyrate;
potassium beta-hydroxybutyrate;
calcium beta-hydroxybutyrate;
magnesium beta-hydroxybutyrate;
and
amino acid salts of beta-hydroxybutyrate;
and
a compound that causes a rise in blood ketone level without adding more electrolytes to the subject's bloodstream,
wherein the composition is in solid and/or powder form,
wherein the composition is free of medium chain fatty acids having 6 to 12 carbons and glycerides or other esters thereof.

14 more elements

Dependencies are inferred from the claim text.

Facts

Application

17/557,429Filed 21 Dec 2021

Priority

11 Mar 2016

Published

14 Apr 2022

Term ends

Not estimatedThe source records don’t support an estimate.

Classification28 codes

A61K 31/19
Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids: carboxylic acids, e.g. valproic acid
A23L 33/12
Fatty acids or derivatives thereof; Fats or oils: fatty acids or derivatives thereof
A23L 33/16
Using additives: inorganic salts, minerals or trace elements
A23L 33/175
Amino acids, peptides or proteins: amino acids

Family

Application62/307,203Us provisional application · filed 11 Mar 2016

Application15/454,157Continuation in part · filed 9 Mar 2017

Application16/272,145Division · filed 11 Feb 2019

Application16/720,211Continuation in part · filed 19 Dec 2019

Application16/996,509Continuation · filed 18 Aug 2020

Application17/198,634Continuation · filed 11 Mar 2021

Application17/557,429Continuation

Application16/996,509Continuation in part

Application16/720,211Division

Application16/272,145Continuation in part

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