Compositions and methods for treating the vertebral column
AssigneeBioMimetic Therapeutics, LLC
InventorsCharles Hart, Samuel E. Lynch, Conan Young, Dan Perrien
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Abstract
The present invention relates to compositions and methods useful for treating structures of the vertebral column, including vertebral bodies. In one embodiment, a method for promoting bone formation in a vertebral body comprising providing a composition comprising a PDGF solution and a biocompatible matrix and applying the composition to at least one vertebral body. Promoting bone formation in a vertebral body, according to some embodiments, can increase bone volume, mass, and/or density leading to an increase in mechanical strength of the vertebral body treated with a composition of the present invention.
Claims21
1-14. (canceled)
A method for increasing bone density in at least one vertebral body of a patient comprising:
- applying to the vertebral body a composition comprising:
- a) a biocompatible matrix having incorporated therein a solution of platelet derived growth factor (PDGF) at a concentration in a range of about 0.1 mg/ml to about 1.0 mg/ml in a buffer, wherein the biocompatible matrix comprises (i) particles of a porous calcium phosphate in a range of about 100 μm to about 3 mm in size or (ii) (a) particles of a porous calcium phosphate in a range of about 100 μm to about 3 mm in size and (b) collagen, wherein the calcium phosphate comprises interconnected pores and a porosity greater than 50%, and
- b) b) a contrast agent.
Dependencies are inferred from the claim text.