Apparatus and Method For Delivery of Antimicrobial During a Transdermal Sampling and Delivery Process
AssigneeGeorgetown University
InventorsMakarand Paranjape, Shruti M. Paranjape
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Abstract
A device for introducing at least one antimicrobial in an exposed region of a user's skin caused while accessing interstitial fluid includes a substrate having thereon at least one electrically controllable microheating element including at least a microheater portion with multiple electrodes connected to the microheater portion for forming a micropore in the user's skin. A nanofiber mat loaded with at least one antimicrobial material is arranged on the substrate such that it contacts the user's skin and encircles an opening of the micropore formed by the microheating element. In a preferred embodiment, the at least one antimicrobial material is LL-37.
Claims18
A device for introducing at least one antimicrobial in an exposed region of a user's skin caused while accessing interstitial fluid of a user comprising:
- a substrate having thereon
- a mechanism for accessing the interstitial fluid of the user having at least one electrically controllable microheating element including at least a microheater portion with multiple electrodes connected to the microheater portion for causing a micropore in the user's skin by thermal ablation of at least a portion of the skin's stratum corneum;
- and
- a nanofiber mat loaded with at least one antimicrobial material, wherein the nanofiber mat is disposed on a skin-facing side of the substrate and is arranged on the skin-facing side such that it contacts the user's skin and encircles an opening of the micropore.
A hand-held device for electrochemically monitoring an analyte in interstitial fluid of a user comprising:
- a first end configured to contact the skin of the user, the first end including a mechanism for ablating the skin of the user to form a micropore to access interstitial fluid and further including a nanofiber mat formed thereon, the nanofiber mat including at least one antimicrobial material;
- a cartridge connected to the first end and having disposed therein a plurality of disposable sensing elements for contacting interstitial fluid from the micropore to monitor an analyte therein;
- a second end connected electrically and mechanically to the cartridge and the first end for facilitating operation of the mechanism for ablating the skin, dispensing of a disposable sensing element and monitoring of the analyte.
A patch including multiple individually controllable sites for accessing interstitial fluid of a user and monitoring at least one analyte therein, comprising:
- a substrate having formed thereon the multiple individually controllable sites each including:
- a mechanism for producing a micropore in the user's skin and accessing the interstitial fluid of the user the mechanism having at least one electrically controllable microheating element including at least a microheater portion with multiple electrodes connected to the microheater portion for producing the micropore in the user's skin by thermal ablation of at least a portion of the skin's stratum corneum;
- and
- a nanofiber mat loaded with at least one antimicrobial material, wherein the nanofiber mat is disposed on a skin-facing side of the substrate and is arranged on the skin-facing side such that it contacts the user's skin and encircles an opening of the micropore;
- and
- an adhesive disposed on the skin-facing side of the substrate for adhering the patch to the skin of the user.
Dependencies are inferred from the claim text.