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US 2022/0101955 A1Published application
Adaptive sorting for particle analyzers
AssigneeBecton, Dickinson and Company
InventorsJonathan Lin, Joseph Trotter, Keegan Owsley
Life of this patent
Estimating the term…
Abstract
A cell sorting system that automatically generates a sorting strategy based on examples of target events provided by an operator. The target events can be selected using measurements ranging from traditional flow cytometry measurements to derived measurements that are computationally expensive to complex measurements such as images.
Claims16
A computer-implemented method comprising:
- under control of one or more processing devices,
- receiving, from a communication device, a reference sorting criteria for a sample with a particle analyzer;
- identifying candidate event classifiers for the sample based at least in part on the reference sorting criteria and the sample;
- generating a sorting strategy, the sorting strategy including at least one event classifier from the candidate event classifiers;
- generating a metric indicating an accuracy of the sorting strategy;
- determining that the metric meets or exceeds a minimum accuracy threshold for the sample;
- and
- configuring the particle analyzer to classify a particle for the sample based at least in part on a multidimensional measurement for the particle and a sorting strategy.
5 more elements
A system comprising:
- one or more processing devices;
- and
- a computer-readable storage medium comprising instructions that, when executed by the one or more processing devices, causes the system to,
- receive, from a communication device, a reference sorting criteria for a sample with a particle analyzer;
- identify candidate event classifiers for the sample based at least in part on the reference sorting criteria and the sample;
- generate a sorting strategy, the sorting strategy including at least one event classifier from the candidate event classifiers;
- generate a metric indicating an accuracy of the sorting strategy;
- determine that the metric meets or exceeds a minimum accuracy threshold for the sample;
- generate a control signal to adjust an operational state for an analytical means included in the particle analyzer, wherein the operational state reflects the sorting strategy;
- and
- transmit the control signal to the analytical means to achieve the operational state.
8 more elements
A method of dynamically processing event data using a parametric machine learning transformation according to any of the embodiments disclosed herein.
Dependencies are inferred from the claim text.