Compositions and methods comprising histidyl-trna synthetase splice variants having non-canonical biological activities

(canceled)

13-15. (canceled)

An oligonucleotide that specifically hybridizes to a polynucleotide of SEQ ID NO:5, 8, or 10.

(canceled)

19-21. (canceled)

A method of determining presence or levels of a polynucleotide sequence of a histidyl-tRNA synthetase (HRS) splice variant in a sample, comprising:

• contacting the sample with one or more oligonucleotides that specifically hybridize to an HRS splice variant as set forth SEQ ID NOS:5, 8, or 10, detecting the presence or absence of the oligonucleotides in the sample, and thereby determining the presence or levels of the polynucleotide sequence of the HRS splice variant;
• or
• contacting the sample with at least two oligonucleotides that specifically amplify an HRS splice variant as set forth in SEQ ID NOS:5, 8, or 10, performing an amplification reaction, detecting the presence or absence of an amplified product, and thereby determining presence or levels of the polynucleotide sequence of the HRS splice variant.

23-27. (canceled)

A method of identifying a compound that specifically binds to a histidyl-tRNA synthetase (HRS) splice variant polypeptide as set forth in SEQ ID NOS:6, 9, or 11, or one or more of its cellular binding partners, comprising a) combining the HRS polypeptide or its cellular binding partner or both with at least one test compound under suitable conditions, and b) detecting binding of the HRS polypeptide or its cellular binding partner or both to the test compound, thereby identifying a compound that specifically binds to the HRS polypeptide or its cellular binding partner or both.

29-48. (canceled)