US 2022/0098292 A1 · SH3YL1 Antibodies, Compositions Comprising the Same, and Vectors and Uses Thereof

Abstract

The present disclosure relates to SH3YL1 monoclonal antibodies and compositions comprising the SH3YL1 monoclonal antibodies. The disclosure also relates to isolated nucleic acid molecules encoding the SH3YL1 antibodies, vectors comprising the nucleic acid molecules, and host cells comprising the vectors. Also disclosed are methods of modulating an immune response, methods of treating diabetic nephropathy, and methods of treating non-alcoholic steatosis hepatitis comprising administering the SH3YL1 antibodies. Also disclosed are methods of treating acute kidney injury and methods of treating inflammatory bowel disease comprising administering the SH3YL1 antibodies.

Claims33

Dependent claims

A monoclonal antibody comprising:

(a) a heavy chain variable region comprising
a heavy chain complementarity determining region 1 (CDR1) comprising the amino acid sequence NYAMS (SEQ ID NO:13),
a heavy chain CDR2 comprising the amino acid sequence VISSDNSSTYYADSVKG (SEQ ID NO:14), and
a heavy chain CDR3 comprising the amino acid sequence VWRHFDY (SEQ ID NO:15);
(b) a light chain variable region comprising
a light chain CDR1 comprising the amino acid sequence SGSSSNIGSNNVN (SEQ ID NO:16),
a light chain CDR2 comprising the amino acid sequence ADSHRPS (SEQ ID NO:17), and
a light chain CDR3 comprising the amino acid sequence ASWDSSLSGYV (SEQ ID NO:18);
(c) a heavy chain variable region comprising
a heavy chain CDR1 comprising the amino acid sequence NYYMS (SEQ ID NO:19),
a heavy chain CDR2 comprising the amino acid sequence AISHNNSNTYYADSVKG (SEQ ID NO:20), and
a heavy chain CDR3 comprising the amino acid sequence KFSFFDY (SEQ ID NO:21);
or
(d) a light chain variable region comprising
a light chain CDR1 comprising the amino acid sequence SGSSSNIGSNYVS (SEQ ID NO:22),
a light chain CDR2 comprising the amino acid sequence ANSHRPS (SEQ ID NO:23), and
a light chain CDR3 comprising the amino acid sequence GAWDSSLNGYV (SEQ ID NO:24).

14 more elements

A monoclonal antibody comprising:

(a) a heavy chain variable region comprising
a heavy chain complementarity determining region 1 (CDR1) comprising the amino acid sequence of SEQ ID NO:63,
a heavy chain CDR2 comprising the amino acid sequence of SEQ ID NO:64, and
a heavy chain CDR3 comprising the amino acid sequence of SEQ ID NO:65;
(b) a light chain variable region comprising
a light chain CDR1 comprising the amino acid sequence of SEQ ID NO:66,
a light chain CDR2 comprising the amino acid sequence of SEQ ID NO:67, and
a light chain CDR3 comprising the amino acid sequence of SEQ ID NO:68;
(c) a heavy chain variable region comprising
a heavy chain CDR1 comprising the amino acid sequence of SEQ ID NO:69,
a heavy chain CDR2 comprising the amino acid sequence of SEQ ID NO:70, and
a heavy chain CDR3 comprising the amino acid sequence of SEQ ID NO:71;
(d) a light chain variable region comprising
a light chain CDR1 comprising the amino acid sequence of SEQ ID NO:72,
a light chain CDR2 comprising the amino acid sequence of SEQ ID NO:73, and
a light chain CDR3 comprising the amino acid sequence of SEQ ID NO:74;
(e) a heavy chain variable region comprising
a heavy chain CDR1 comprising the amino acid sequence of SEQ ID NO:69,
a heavy chain CDR2 comprising the amino acid sequence of SEQ ID NO:75, and
a heavy chain CDR3 comprising the amino acid sequence of SEQ ID NO:76;
(f) a light chain variable region comprising
a light chain CDR1 comprising the amino acid sequence of SEQ ID NO:77,
a light chain CDR2 comprising the amino acid sequence of SEQ ID NO:78, and
a light chain CDR3 comprising the amino acid sequence of SEQ ID NO:79;
(g) a heavy chain variable region comprising
a heavy chain CDR1 comprising the amino acid sequence of SEQ ID NO:69,
a heavy chain CDR2 comprising the amino acid sequence of SEQ ID NO:80, and
a heavy chain CDR3 comprising the amino acid sequence of SEQ ID NO:81;
(h) a light chain variable region comprising
a light chain CDR1 comprising the amino acid sequence of SEQ ID NO:82,
a light chain CDR2 comprising the amino acid sequence of SEQ ID NO:83, and
a light chain CDR3 comprising the amino acid sequence of SEQ ID NO:84;
(i) a heavy chain variable region comprising
a heavy chain CDR1 comprising the amino acid sequence of SEQ ID NO:13,
a heavy chain CDR2 comprising the amino acid sequence of SEQ ID NO:85, and
a heavy chain CDR3 comprising the amino acid sequence of SEQ ID NO:86;
(j) a light chain variable region comprising
a light chain CDR1 comprising the amino acid sequence of SEQ ID NO:87,
a light chain CDR2 comprising the amino acid sequence of SEQ ID NO:88, and
a light chain CDR3 comprising the amino acid sequence of SEQ ID NO:74;
(k) a heavy chain variable region comprising
a heavy chain CDR1 comprising the amino acid sequence of SEQ ID NO:89,
a heavy chain CDR2 comprising the amino acid sequence of SEQ ID NO:90, and
a heavy chain CDR3 comprising the amino acid sequence of SEQ ID NO:91;
(l) a light chain variable region comprising
a light chain CDR1 comprising the amino acid sequence of SEQ ID NO:92,
a light chain CDR2 comprising the amino acid sequence of SEQ ID NO:73, and
a light chain CDR3 comprising the amino acid sequence of SEQ ID NO:74;
(m) a heavy chain variable region comprising
a heavy chain CDR1 comprising the amino acid sequence of SEQ ID NO:93,
a heavy chain CDR2 comprising the amino acid sequence of SEQ ID NO:94, and
a heavy chain CDR3 comprising the amino acid sequence of SEQ ID NO:95;
or
(n) a light chain variable region comprising
a light chain CDR1 comprising the amino acid sequence of SEQ ID NO:96,
a light chain CDR2 comprising the amino acid sequence of SEQ ID NO:97, and
a light chain CDR3 comprising the amino acid sequence of SEQ ID NO:74.

54 more elements

Dependencies are inferred from the claim text.

SH3YL1 Antibodies, Compositions Comprising the Same, and Vectors and Uses Thereof

Life of this patent

SH3YL1 Antibodies, Compositions Comprising the Same, and Vectors and Uses Thereof

Life of this patent

Abstract

Claims33