Reformulating Hospital Gentamicin to reduce the risk of hearing loss while maintaining antimicrobial activity

Abstract

Reformulations of gentamicin for treatment of infections are provided with the goal to reduce current side effects such as ototoxicity, while maintaining antimicrobial activity. The reformulation is a mixture of three of the C-components of gentamicin: C1a, C2a and C2b, while excluding as much as possible, C1 and C2. Specifically, to the objective of this invention a mixture is formulated having gentamicin C1a ranging from 10-30%, gentamicin C2a ranging from 0-30%, and gentamicin C2b ranging from 40-90%, where the mixture totals a 100% of the gentamicin C-components, defined as C1, C1a, C2, C2a and C2b only. The formulations of this invention increase the probability of a more favorable outcome for the patients exposed to gentamicin, i.e., reduced risk of the side-effect of hearing loss.

Dependencies are inferred from the claim text.