Methods for analyzing a tissue sample
AssigneePurdue Research Foundation
InventorsYu Xia, Zheng Ouyang, Xiaoxiao Ma
Life of this patent
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Abstract
The invention generally relates to methods for analyzing a tissue sample. In certain aspects, the invention provides methods that involve obtaining a tissue sample including an unsaturated compound, conducting a radical reaction on the tissue sample that targets a carbon-carbon double bond within the unsaturated compound to thereby produce a plurality of compound isomers, subjecting the plurality of compound isomers to mass spectrometry analysis to identify a location of the carbon-carbon double bond within the unsaturated compound, and quantifying the plurality of compound isomers in order to distinguish normal tissue from diseased tissue.
Claims8
1-20. (canceled)
A method for imaging a tissue sample, the method comprising:
- introducing reagents for a radical reaction to a tissue comprising an unsaturated compound, wherein the radical reaction targets a carbon-carbon double bond within the unsaturated compound;
- conducting the radical reaction to produce reaction products;
- scanning the tissue such that the reaction products are desorbed and ionized in a time resolved manner;
- analyzing the desorbed and ionized reaction products in a mass spectrometer;
- and
- producing an image of the tissue based on results of the analyzing step.
Dependencies are inferred from the claim text.