De novo generation of high diversity proteins in silico with selective affinity and cross-reactivity minimization
AssigneeThaumachron LLC
InventorAndrew Simpson
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Abstract
This disclosure relates to a platform for de novo in silico generation of high diversity protein complexes, namely antibodies and TCRs, with selective affinity and cross-reactivity minimization given the antigen complex's sequences and additional conditional information.
Claims3
The platform can generate high diversity de novo protein complexes in silico, namely antibodies and TCRs, for a specific antigen complex with selective affinity and cross-reactivity minimization given the antigen complex's sequences and additional conditional information.
The platform can take into account an individual's allelic differences in order to produce personalized high diversity protein complexes targeted for specific antigen complexes.
The platform outputs high diversity protein complex and antigen complex sequences, distance matrices, angle information, surface mesh representations, and epitope information that can be used to further facilitate research and development of the desired high diversity protein complexes.
Dependencies are inferred from the claim text.