Predicting immunogenicity of t cell epitopes
AssigneesBioNTech SE, TRON-Translationale Onkologie an der Universitatsmedizin der Johannes Gutenberg-Universitat Mainz gG
InventorsUgur Sahin, Arbel David Tadmor, John Christopher Castle, Sebastian Boegel, Martin Löwer
Life of this patent
Estimating the term…
Abstract
The present invention relates to methods for predicting T cell epitopes. In particular, the present invention relates to methods for predicting whether modifications in peptides or polypeptides such as tumor-associated neoantigens are immunogenic or not. The methods of the invention are useful, in particular, for the provision of vaccines which are specific for a patient's tumor and thus, in the context of personalized cancer vaccines.
Claims42
A method for predicting immunogenic amino acid modifications, the method comprising the steps:
- a) ascertaining a score for binding of a modified peptide to one or more MHC molecules, and
- b) ascertaining a score for binding of the non-modified peptide to one or more MHC molecules, and/or
- c) ascertaining a score for binding of the modified peptide when present in a MHC-peptide complex to one or more T cell receptors.
Dependencies are inferred from the claim text.