Stomach simulating device

A stomach simulating device comprising:

• a conduit having a body portion, a first diameter at an inlet portion, and a second diameter at an outlet portion, wherein the first diameter at the inlet portion is located between the inlet portion and the outlet portion, and at least a portion of the conduit is curved in a direction from the inlet portion the outlet portion;
• and
• a mechanical constrictor configured to constrict at least a portion of the body portion of the conduit.

A stomach simulating device comprising:

• a conduit having a body portion, a first diameter at an inlet portion, and a second diameter at an outlet portion, wherein the first diameter at the inlet portion is greater than the second diameter at the outlet portion, the body portion is located between the inlet portion and the outlet portion, and at least a portion of the conduit is curved in a direction from the inlet portion the outlet portion;
• and
• a valve configured to at least partially close a portion of the conduit closer to the outlet portion than the inlet portion of the conduit.

A method of simulating a stomach comprising:

• inserting a dosage form to be tested into an inlet portion of a conduit, the conduit having a body portion located between the inlet portion and an outlet portion, wherein at least a portion of the conduit is curved in a direction from the inlet portion the outlet portion;
• applying a radial force to the conduit while the dosage form is in the conduit and a valve at least partially constricts a portion of the conduit closer to the outlet portion than the inlet portion of the conduit.

A stomach simulating device comprising:

• a conduit having a body portion, a first inner diameter, and a second inner diameter, and an outer diameter, wherein the first inner diameter is larger than the second inner diameter;
• and
• a plurality of cable constrictors, wherein each cable constrictor of the plurality of cable constrictors is configured to constrict a portion of the body portion of the conduit.