Method and system for determining a significance score associated with a medical imaging dataset of a patient

A system for determining a significance score associated with a medical imaging dataset of a patient, the medical imaging dataset including image data of a region of an anatomy of a patient including a plurality of coronary arteries, the system comprising:

• a first interface to receive the medical imaging data set;
• a partitioning unit to automatically partition each respective coronary artery of the plurality of coronary arteries into one or more coronary artery segments;
• a first extraction unit to extract a representation of a corresponding section of the respective coronary artery from the medical imaging data set;
• a second extraction unit to extract a one or more features from the representation of the corresponding section of the respective coronary artery;
• a combining unit to perform a combining operation, based on features extracted for all of the one or more coronary segments to obtain a global set of features based on respective quantitative information for each respective coronary segment;
• a calculation unit to determine the significance score based on the global set of features;
• and
• a second interface to provide the significance score determined.