Cancer detection utilizing normal tissue adjacent to breast tumors with genetic ancestry-mapping
AssigneeThe Trustees of Indiana University
InventorHarikrishna NAKSHATRI
Life of this patent
Estimating the term…
Abstract
Methods and compositions are provided for detecting and/or determining a patient's risk of cancer. The methods utilize categorizing the source of biopsy samples based on patient ancestry mapping in combination with cancer markers to identify patients at higher risk of cancer.
Claims24
1-4. (canceled)
A method of analyzing potential cancer or pre-cancer biopsy samples of patients of European Ancestry or African Ancestry, said method comprising:
- obtaining a potential cancer or pre-cancer biopsy sample recovered from patient tissues;
- categorizing said sample based on ancestry mapping of the patient source of said sample;
- and
- quantifying the level of expression in said categorized sample of a protein marker selected from a group consisting of ZEB1, FOXA1, and GATA3, or a combination thereof.
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An improved method of treating cancer in a patient of European Ancestry or African Ancestry, said method comprising the steps of
- obtaining a tissue biopsy sample identified as being cancer by radiological techniques and categorized as being from a patient of European Ancestry or African Ancestry;
- analyzing said sample for an increased level of ZEB1+ cells and decreased levels of FOXA1+ cells compared to a relevant true normal sample or relevant true normal population data;
- identifying patients of European Ancestry and having an increased level of ZEB1+ cells;
- identifying patients of African Ancestry and having decreased levels of FOXA1+ cells;
- and
- treating said identified patients of European Ancestry and patients of African Ancestry using anti-cancer therapies.
An improved method of analyzing a pre-cancer or cancerous biopsy in a patient who is duffy-null/heterozygous, said method comprising the steps of
- analyzing a tissue biopsy sample obtained from said patient and identified as cancerous or pre-cancerous using radiology techniques;
- and
- quantifying the levels of phospho-c-MET in the patient sample.
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A kit for detecting and quantitating the relative number of ZEB1+ cells and FOXA1+ cells in a tissue sample recovered from a patient, said kit comprising
- a reagent for the detection of ZEB1+ cells;
- and
- a reagent for the detection of FOXA1+ cells.
The kit claim of 21 further comprising a reagent for detecting GATA3.
The kit claim of 21 further comprising a reagent for detecting phospho-c-MET.
An improved method of analyzing a pre-cancerous or cancerous biopsy sample from a patient of European Ancestry, said method comprising the steps of
- analyzing the biopsy sample identified as pre-cancerous or cancerous using radiology techniques;
- and
- quantifying the number of GATA3+ cells.
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Dependencies are inferred from the claim text.