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US 2022/0091120 A1Published application
Method for identifying modulators of g3bp activity
AssigneeSt. Jude Children's Research Hospital
InventorsJ. Paul TAYLOR, Peiguo YANG, Wenwei LIN, Taosheng CHEN
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Abstract
A method of identifying a lead or candidate compound that modulates the activity of GTPase-Activating Protein SH3 Domain-Binding Proteins (G3BP) is provided, which includes determining whether a compound modulates the interaction between the N-terminal Nuclear Transport Factor 2-like (NTF2L) domain of G3BP and FGDF peptide of ubiquitin specific protease 10 (USP10) or non-structural protein 3 (nsP3).
Claims10
A kit for identifying a lead or candidate compound that modulates the activity of GTPase-Activating Protein SH3 Domain-Binding Proteins (G3BP) comprising:
- (i) a N-terminal Nuclear Transport Factor 2-like (NTF2L) domain of G3BP and
- (ii) a peptide containing a FGDF motif,
- wherein at least on one of (i) or (ii) is conjugated to a fluorescent acceptor moiety or a tag.
Dependencies are inferred from the claim text.