Methods and compositions for diagnosing neurodegenerative disease
AssigneeBoard of Regents of the University of Nebraska
InventorsHoward E. Gendelman, R. Lee Mosley, Jessica A. Saunders
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Abstract
Methods and compositions for detecting and diagnosing Parkinson's disease are disclosed.
Claims27
A method of diagnosing Parkinson's disease in a subject said method comprising detecting in a biological sample obtained from said subject at least one marker from the C-X-C chemokine receptor type 4 (CXCR-4) or phosphatidylinositol 3-kinase regulatory subunit 1 (alpha) (PIK3R1) signaling pathways,
- wherein a modulation in the amount of said marker compared to healthy individuals is indicative of Parkinson's disease.
A method of diagnosing Parkinson's disease in a subject said method comprising detecting effector memory T cells (Tem) in a biological sample obtained from said subject,
- wherein an increase in the amount of said Tem compared to healthy individuals is indicative of Parkinson's disease.
A method of diagnosing Parkinson's disease in a subject said method comprising measuring the function of regulatory T cells (Treg) in a biological sample obtained from said subject, wherein decreased Treg function is indicative of PD.
A composition comprising at least one antibody for at least one marker selected from the group consisting of PIK3R1, CXCR4, integrin alpha-V (ITGAV), integrin alpha-E (ITGAE), integrin beta-7 (ITGB7), integrin alpha-4 (ITGA4), cluster of differentiation 31 (CD31), secreted phosphoprotein 1 (SPP1), cluster of differentiation 45 (CD45), forkhead box P3 (FoxP3), fibronectin 1 (FN1), CD27, CD4, CD127, CD25, and FAS.
A composition comprising at least one nucleic acid probe for at least one marker selected from the group consisting of PIK3R1, CXCR4, integrin alpha-V (ITGAV), integrin alpha-E (ITGAE), integrin beta-7 (ITGB7), integrin alpha-4 (ITGA4), cluster of differentiation 31 (CD31), secreted phosphoprotein 1 (SPP1), cluster of differentiation 45 (CD45), forkhead box P3 (FoxP3), fibronectin 1 (FN1), CD27, CD4, CD127. CD25, and FAS.
Dependencies are inferred from the claim text.