Analysis of polymorphisms in sirp-alpha for evaluating response to immunotherapy

Abstract

Methods and kits are provided for determining whether an individual is responsive to therapeutic CD47 blockade. Specifically, the disclosure provides methods of determining whether a cell or cell population is responsive to therapeutic CD47 blockade, the method comprising: assaying a cell sample from an individual to determine (a) the level of expression of signal regulatory protein alpha (SIRPalpha) on phagocytic immune cells, or (b) the genotype of the individual at a nucleotide polymorphism (SNP) associated with SIRPalpha expression. Further disclosed are SNPs associated with SIRPalpha expression.

Dependencies are inferred from the claim text.