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US 2022/0091099 A1Published application
Gene editing through microfluidic delivery
AssigneesMassachusetts Institute of Technology, President and Fellows of Harvard College
InventorsArmon R. Sharei, Marc Lajoie, Klavs F. Jensen, Robert S. Langer
Life of this patent
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Abstract
Gene editing can be performed by introducing gene-editing components into a cell by mechanical cell disruption. Related apparatus, systems, techniques, and articles are also described.
Claims29
-33. (canceled)
A microfluidic system for delivering a protein-nucleic acid complex into a cell, comprising at least one microfluidic channel, wherein the microfluidic channel comprises a constriction having a diameter that is 20-99% of the diameter of the cell.
Dependencies are inferred from the claim text.