Chromatographic hardware improvements for separation of reactive molecules
AssigneeWaters Technologies Corporation
InventorsMathew DeLano, Matthew A. Lauber, Kevin Wyndham, Jennifer M. Nguyen
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Abstract
The present disclosure relates to a method of reducing degradation of sample components in a liquid chromatography system. The method utilizes a masked metal frit to prevent or reduce metal surfaces from becoming catalytically active. The masked metal frit is a metal based frit that includes a coating on its exterior surfaces to mask or prevent contact between the organic solvents (and/or any analyte or other related solvent) and the underlying metal. The coating is a vapor deposited inorganic-organic hybrid coating, such as a vapor deposited C2 coating.
Claims28
A chromatography column, comprising:
- a frit comprising a metal substrate and an outer coating surrounding at least a portion of a surface of the substrate, the outer coating comprising an inorganic-organic hybrid.
A method of reducing metal-catalyzed reactions of sample components during liquid chromatography, the method comprising:
- separating a sample in a chromatography column including a masked metal frit, wherein the masked metal frit comprises a metal frit coated on exterior surfaces with an inorganic-organic hybrid coating that is non-reactive with the sample;
- and
- detecting separated sample components with a detector.
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Dependencies are inferred from the claim text.