Method for testing for sensitivity of chemotherapy against colorectal cancer
AssigneesTohoku University, Riken Genesis Co., Ltd.
InventorsCHIKASHI ISHIOKA, SHIN TAKAHASHI, KOUTA OUCHI, AKIRA OKITA, TATSURO SAITO, JUNKO NAKAMURA, AKIHIRO TSUYADA
Life of this patent
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Abstract
A method for testing for sensitivity of chemotherapy against colorectal cancer, the method using, as an indicator, methylation in at least one site selected from the group consisting of CpG sites comprised in regions (i) to (xvi) in DNA collected from a colorectal cancer patient (the regions (i) to (xvi) are as described herein).
Claims17
A method for testing for sensitivity of chemotherapy against colorectal cancer, the method using, as an indicator, methylation in at least one site selected from the group consisting of CpG sites comprised in the following regions (i) to (xvi) in DNA collected from a colorectal cancer patient:
- Region (i):
- a region at positions 207307150 to 207309004 of chromosome 2
- Region (ii):
- a region at positions 241758282 to 241760510 of chromosome 2
- Region (iii):
- a region at positions 150802997 to 150805168 of chromosome 3
- Region (iv):
- a region at positions 141347993 to 141348489 of chromosome 4
- Region (v):
- a region at positions 186048714 to 186050048 of chromosome 4
- Region (vi):
- a region at positions 17216679 to 17219240 of chromosome 5
- Region (vii):
- a region at positions 37663982 to 37664539 of chromosome 6
- Region (viii):
- a region at positions 39281183 to 39282332 of chromosome 6
- Region (ix):
- a region at positions 42273390 to 42277951 of chromosome 7
- Region (x):
- a region at positions 13039715 to 13043422 of chromosome 10
- Region (xi):
- a region at positions 81664401 to 81665076 of chromosome 10
- Region (xii):
- a region at positions 88126287 to 88127189 of chromosome 10
- Region (xiii):
- a region at positions 61595807 to 61/596,627 of chromosome 11
- Region (xiv):
- a region at positions 23820337 to 23822266 of chromosome 14
- Region (xv):
- a region at positions 44895317 to 44896749 of chromosome 17
- Region (xvi):
- a region at positions 39520228 to 39523159 of chromosome 19.
A kit for acquiring information that can be an indicator of presence or absence of sensitivity of chemotherapy against colorectal cancer, the kit comprising a primer set for analyzing methylation in at least one site selected from the group consisting of CpG sites comprised in the following regions (i) to (xvi) in DNA collected from a colorectal cancer patient:
- Region (i):
- a region at positions 207307150 to 207309004 of chromosome 2
- Region (ii):
- a region at positions 241758282 to 241760510 of chromosome 2
- Region (iii):
- a region at positions 150802997 to 150805168 of chromosome 3
- Region (iv):
- a region at positions 141347993 to 141348489 of chromosome 4
- Region (v):
- a region at positions 186048714 to 186050048 of chromosome 4
- Region (vi):
- a region at positions 17216679 to 17219240 of chromosome 5
- Region (vii):
- a region at positions 37663982 to 37664539 of chromosome 6
- Region (viii):
- a region at positions 39281183 to 39282332 of chromosome 6
- Region (ix):
- a region at positions 42273390 to 42277951 of chromosome 7
- Region (x):
- a region at positions 13039715 to 13043422 of chromosome 10
- Region (xi):
- a region at positions 81664401 to 81665076 of chromosome 10
- Region (xii):
- a region at positions 88126287 to 88127189 of chromosome 10
- Region (xiii):
- a region at positions 61595807 to 61/596,627 of chromosome 11
- Region (xiv):
- a region at positions 23820337 to 23822266 of chromosome 14
- Region (xv):
- a region at positions 44895317 to 44896749 of chromosome 17
- Region (xvi):
- a region at positions 39520228 to 39523159 of chromosome 19.
Dependencies are inferred from the claim text.