Diagnosis and treatment of psoriatic arthritis
AssigneeChang Gung Memorial Hospital, Kaohsiung
InventorsShang-Hung LIN, Chih-Hung LEE, Chang-Chun HSIAO
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Abstract
Methods and kits for diagnosing or predicting the risk of developing psoriatic arthritis in a subject in need of such diagnosis or risk prediction are provided, comprising measuring the expression level of one or more miRNAs disclosed herein in the sample of the subject, and compared the expression level of at least one of the miRNAs in the test sample with that of the psoriatic arthritis-free sample. Also provided are methods of treating psoriatic arthritis by reducing the expression level of at least one of the miRNAs disclosed herein.
Claims12
A method for detecting or predicting the risk of developing psoriatic arthritis and treating psoriatic arthritis in a subject in need thereof, comprising the step of
- (a) obtaining a test sample from the subject, wherein the subject exhibits one or more symptoms of psoriatic arthritis or is at risk of developing psoriatic arthritis;
- (b) measuring the expression level of miR-146a-5p in the test sample of the subject;
- (c) identifying the subject as having psoriatic arthritis or has a risk of developing psoriatic arthritis if the expression level of at least one miRNA in the test sample in step (b) is higher relative to the expression level of at least one corresponding miRNA in a psoriatic arthritis-free sample;
- (d) administering to the subject a therapeutic agent to treat psoriatic arthritis.
Dependencies are inferred from the claim text.