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AssigneeAcademy of Military Medical Sciences
InventorsShengqi WANG, Qiqi LIU, Liyan LIU, Ying ZHANG, Yi ZHAO
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Disclosed by the present application are a structure of a double-stranded oligonucleotide nucleic acid probe, a method of use and applications thereof in nucleic acid fluorescence qualitative and quantitative analysis, medical diagnosis and life science researches. The double-stranded oligonucleotide nucleic acid probe is composed of two completely or partially base-complementary oligonucleotide strands; the end of each oligonucleotide strand may be connected to a fluorescent group or a corresponding fluorescent quenching group; and the two oligonucleotide probe strands may hybridize with a target nucleic acid sequence to be tested.
A double-stranded oligonucleotide nucleic acid probe structure, consisting of two completely or partially base-complementary oligonucleotide chains, wherein two probes each independently consist of 6-50 oligonucleotides, an end of each oligonucleotide chain is able to be linked to a fluorescent group or a corresponding fluorescent quenching group, and two oligonucleotide probe chains are both able to be hybridized and bound with a partial fragment of a target DNA or RNA nucleic acid sequence to be detected according to a base pairing principle.
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