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US 2022/0090137 A1Published application
Methods and compositions for circular rna molecules
AssigneeThe University of North Carolina at Chapel Hill
InventorsAravind Asokan, Erin Borchardt, Rita Meganck, William F. Marzluff
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Abstract
This invention is directed to AAV compositions for circular RNA expression and methods of expressing covalently closed, circular RNA.
Claims30
An adeno-associated virus (AAV) genome encoding a circular RNA, wherein the AAV genome comprises, from 5′ to 3′:
- (a) a first inverted terminal repeat;
- (b) a first intronic element;
- (c) a nucleotide sequence of interest;
- (d) a second intronic element;
- and
- (d) a second inverted terminal repeat.
3 more elements
Dependencies are inferred from the claim text.