Sin nombre virus full-length m segment-based dna vaccines
AssigneeThe Government of the United States, as represented by the Secretary of the Army
InventorJay HOOPER
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Abstract
The invention contemplates a new synthetic, codon-optimized Sin Nombre virus (SNV) full-length M gene open reading frame (ORF) that encodes a unique consensus amino acid sequence. The SNV ORF was cloned into a plasmid to form the first stable recombinant SNV full-length M gene that elicits neutralizing antibodies. The gene can be engineered into a vaccine system, and is useful to protect mammals against infection with Sin Nombre virus.
Claims1
A therapeutic composition for ameliorating symptoms after onset of Sin Nombre virus infection comprising antibodies specific for peptides encoded by the nucleic acid having the sequence set forth in SEQ ID NO:3.
Dependencies are inferred from the claim text.