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US 2022/0090102 A1Published application
Sulfite tolerance in recombinant yeast host cells
AssigneeLallemand Hungary Liquidity Management LLC
InventorsAaron Argyros, Charles F. Rice, Trisha Barrett, Michelle Oeser, Janet Fisher
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Abstract
The present disclosure concerns the use of specific genetic modification(s) for improving sulfite tolerance in recombinant yeast host cells. The genetic modification(s) is (are) designed to allow the expression of an heterologous transcription factor favoring the expression of a SSU1 polypeptide and/or the expression of an heterologous SSU1 polypeptide in the recombinant yeast host cell(s).
Claims25
A recombinant yeast host cell comprising:
- a first genetic modification for reducing the production of one or more native enzymes that function to produce glycerol or regulate glycerol synthesis and/or allowing the production of an heterologous glucoamylase;
- and
- (ii) a second genetic modification allowing the expression of an heterologous transcription factor favoring the expression of a SSU1 polypeptide and/or allowing the expression of an heterologous SSU1 polypeptide.
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Dependencies are inferred from the claim text.