Compositions and methods for induced tissue regeneration in mammalian species
AssigneeAgeX Therapeutics, Inc.
InventorsMichael D. West, Karen Chapman, Hal Sternberg
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Abstract
Aspects of the present invention include methods and compositions related to the modulation of molecules regulating the regenerative potential of cells and tissues in the embryonic state and the loss thereof in later fetal and adult stages of development. Said methods and compositions have uses in research in stem cell biology and in increasing regenerative potential in fetal and adult tissues otherwise incapable of regeneration.
Claims44
-26. (canceled)
A method of regenerating tissue in a subject comprising administering to the cells of the tissue a composition comprising one or more de-differentiation genes or gene products selected from the group consisting of SOX2, KLF4, OCT4, MYC, NANOG, and LIN28.
A method of regenerating tissue in a subject comprising administering to the cells of the tissue a composition comprising:
- a. one or more de-differentiation genes or gene products selected from the group consisting of SOX2, KLF4, OCT4, MYC, NANOG, and LIN28;
- and
- b. one or more of the genes or gene products selected from the group consisting of PCDHB2, PCDHB17, Nbla10527, RAB3IP, DLX1, DRD11P, FOXD1, LOC728755, AFF3, F2RL2, MN1, CBCAQH03 5, LOC791120, SIX1, OXTR and WSB1.
Dependencies are inferred from the claim text.