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AssigneeThe Research Foundation for The State University of New York
InventorsJingfang Ju, Andrew Fesler, Younghwa Song, Jun Chung
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The present disclosure provides nucleic acid compositions that incorporate one or more halouracil molecules. More specifically, the present disclosure reveals that the replacement of uracil nucleotides within a microRNA nucleotide sequence with a 5-halouracil increases the ability of the micro-RNA to inhibit cancer progression and tumorigenesis. As such, the present disclosure provides various nucleic acid (e.g., microRNA) compositions having 5-halouracil molecules incorporated in their nucleic acid sequences and methods for using the same. The present disclosure further provides pharmaceutical compositions comprising the modified nucleic acid compositions, and methods for treating cancers using the same.
A modified microRNA nucleic acid composition comprising a nucleotide sequence having at least one uracil nucleic acid, wherein one or more of said at least one uracil nucleic acids is a 5-fluorouracil, and wherein the modified microRNA nucleic acid composition binds to a portion of a MDC1 3′UTR nucleotide sequence set forth in SEQ ID NO:
The pharmaceutical composition of claim 10, wherein said modified microRNA composition comprises a nucleotide sequence of CGACGGCAUFAUFACACUFACAGUFG [SEQ ID NO. 32].
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Dependencies are inferred from the claim text.