Transferrin receptor-binding molecules, conjugates thereof and their uses
AssigneesVect-Horus, Universite D'Aix-Marseille, Centre National De La Recherche Scientifique
InventorsROMY COHEN, MARION DAVID, MICHEL KHRESTCHATISKY
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Abstract
The invention relates to Variable Domain of Camelid Heavy Chain-only (VHH) molecules which bind TfR and the uses thereof e.g., to transport molecules of pharmaceutical or diagnostic interest into cells and in organs, in pathological conditions including cancer.
Claims21
1-29. (canceled)
A VHH molecule of formula FR1-CDR1-FR2-CDR2-FR3-CDR3-FR4, wherein said VHH molecule binds both a human and a non-human animal TfR with an affinity (Kd) comprised between 0.1 nM and 10 μM, optionally conjugated to at least one molecule or scaffold.
Dependencies are inferred from the claim text.