Novel nanoparticles using anionic polymer, preparation method and composition thereof
AssigneeImgt Co., Ltd.
InventorsSeung Ki KIM, Hyun Ryoung KIM, Eun Ah JUNG, Woo Ram CHO
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Abstract
The present invention relates to novel nanoparticles using an anionic polymer, a preparation method thereof, a composition, and the like, and the present invention is used for a method of necrosing cancer cells by blocking major blood vessels that supply nutrients to cancer cells to induce an embolic effect, and thus may be used for the treatment of patients with cancer.
Claims21
A composition for a vascular embolism and treating cancer, the composition comprising:
- nanoparticles comprising an anionic polymer and a trivalent metal compound salt;
- and
- a cationic drug;
- as active ingredients.
A method for preparing nanoparticles comprising an anionic polymer and a trivalent metal compound salt, the method comprising the following steps:
- forming an emulsion by mixing a solution obtained by adding a water phase in which a polymer is dissolved to an oil phase with a solution in which a non-ionic surfactant is dissolved in a water phase;
- forming microparticles by adding an aqueous trivalent metal compound salt solution to the emulsion;
- and
- reducing particle size of the microparticles to a nano level using one or more selected from the group consisting of a high-pressure homogenizer, a bead mill, and a roll mill.
(canceled)
A method for performing a vascular embolization and treating cancer, the method comprising:
- administering, to an individual, a composition comprising:
- nanoparticles comprising an anionic polymer and a trivalent metal compound salt;
- and
- a cationic drug;
- as active ingredients.
(canceled)
Dependencies are inferred from the claim text.