Monoclonal antibody specifically binding to ccsp-2 and use thereof

A monoclonal antibody specifically binding to the EGF2 domain of colon cancer secreted protein-2 (CCSP-2), which comprises a heavy chain variable region and a light chain variable region, selected from the group consisting of 1) to 4) as follows, or an antigen-binding fragment thereof:

• 1) a heavy chain variable region including a CDR1 region represented by SEQ ID NO:
• 1, a CDR2 region represented by SEQ ID NO:
• 2 and a CDR3 region represented by SEQ ID NO:
• 3, and a light chain variable region including a CDR1 region represented by SEQ ID NO:
• 4, a CDR2 region represented by SEQ ID NO:
• 5 and a CDR3 region SEQ ID NO:
• 6;
• 2) a heavy chain variable region including a CDR1 region represented by SEQ ID NO:
• 7, a CDR2 region represented by SEQ ID NO:
• 8 and a CDR3 region represented by SEQ ID NO:
• 9, and a light chain variable region including a CDR1 region represented by SEQ ID NO:
• 10, a CDR2 region represented by SEQ ID NO:
• 11 and a CDR3 region represented by SEQ ID NO:
• 12;
• 3) a heavy chain variable region including a CDR1 region represented by SEQ ID NO:
• 13, a CDR2 region represented by SEQ ID NO:
• 14 and a CDR3 region represented by SEQ ID NO:
• 15, and a light chain variable region including a CDR1 region represented by SEQ ID NO:
• 16, a CDR2 region represented by SEQ ID NO:
• 17 and a CDR3 region represented by SEQ ID NO:
• 18;
• and
• 4) a heavy chain variable region including a CDR1 region represented by SEQ ID NO:
• 19, a CDR2 region represented by SEQ ID NO:
• 20 and a CDR3 region represented by SEQ ID NO:
• 21, and a light chain variable region including a CDR1 region represented by SEQ ID NO:
• 22, a CDR2 region represented by SEQ ID NO:
• 23 and a CDR3 region represented by SEQ ID NO:
• 24.