Anti-Abeta Antibodies
OwnerMichael SKOV, Tarlochan S. NIJJAR +6inventors
InventorsMichael SKOV, Tarlochan S. NIJJAR, Sridhar GOVINDARAJAN, Tom PURCELL, Mark WELCH, Frédérique BARD, Robin BARBOUR, Wagner ZAGO
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Abstract
Antibodies that bind human beta-amyloid peptide, methods of detecting, measuring and treating amyloidogenic disorders with said antibodies, pharmaceutical compositions comprising the antibodies and methods of manufacture are provided.
Claims20
An antibody or an antigen binding fragment thereof that specifically binds to Aβ peptide, comprising a heavy chain variable region comprising heavy chain CDR1, CDR2, and CDR3 and a light chain variable region comprising light chain CDR1, CDR2, and CDR3, wherein
- heavy chain CDR1 comprises the amino acid sequence of SEQ ID NO:
- 16,
- heavy chain CDR2 comprises the amino acid sequence of SEQ ID NO:
- 20,
- heavy chain CDR3 comprises the amino acid sequence of SEQ ID NO:
- 18,
- light chain CDR1 comprises the amino acid sequence of SEQ ID NO:
- 29,
- light chain CDR2 comprises the amino acid sequence of SEQ ID NO:
- 34, and
- light chain CDR3 comprises the amino acid sequence of SEQ ID NO:
- 38.
A human IgG1 antibody or an antigen binding fragment thereof that specifically binds to Aβ peptide, comprising:
- a) a heavy chain comprising a heavy chain variable region comprising the amino acid sequence of SEQ ID NO:
- 3;
- and
- b) a light chain comprising a light chain variable region comprising the amino acid sequence of SEQ ID NO:
- 9.
A human IgG1 antibody that specifically binds to Aβ peptide, comprising:
- a) a heavy chain comprising
- a variable region comprising the amino acid sequence of SEQ ID NO:
- 3, and
- a constant region comprising the amino acid sequence of SEQ ID NO:
- 40 with or without the C-terminal lysine;
- and
- b) a light chain comprising
- a variable region comprising the amino acid sequence of SEQ ID NO:
- 9, and
- a constant region comprising the amino acid sequence of SEQ ID NO:
- 41.
Dependencies are inferred from the claim text.