Antibody against the endothelin receptor subtype a, and uses thereof
AssigneesCommissariat A L'energie Atomique Et Aux Energies Alternatives, Universite De Paris, Universite De Montpellier, Institut National de la Sante et de la Recherche Medicale
InventorsDidier BOQUET, Amaury HERBET, Frederic DUCANCEL, Narciso COSTA, Jean-Yves COURAUD, Jean-Philippe HUGNOT
Life of this patent
Estimating the term…
Abstract
The present invention relates to antibodies against the endothelin receptor subtype A, in particular monoclonal antibodies, fragments or derivatives thereof. The present invention also relates to the therapeutic or diagnostic use of this antibody or as a research tool in the field of cancers, in particular glioblastoma.
Claims20
Antibody directed against the endothelin receptor subtype A having:
- i) at least one light-chain variable region, wherein the amino acid sequence:
- of the CDR1L has at least 60% identity with the following amino acid sequence:
- SQSIVYSNGKIYL (SEQ ID NO:
- 2);
- of the CDR2L has at least 60% identity with the following amino acid sequence:
- KVS;
- of the CDR3L has at least 60% identity with the following amino acid sequence:
- FQGSHLPLT (SEQ ID NO:
- 4);
- and
- ii) at least one heavy-chain variable region wherein the amino acid sequence:
- of the CDR1H has at least 60% identity with the following amino acid sequence:
- GFTFNIYA (SEQ ID NO:
- 6);
- of the CDR2H has at least 60% identity with the following amino acid sequence:
- IRSKSNNYAT (SEQ ID NO:
- 8);
- of the CDR3H has at least 60% identity with the following amino acid sequence:
- VSSYYSGSFFAY (SEQ ID NO:
- 10);
- a fragment or a derivative thereof.
Hybridoma filed at the CNCM on 18 Oct. 2017 under the number CNCM 1-5250.
Dependencies are inferred from the claim text.