Pdgf receptor beta binding polypeptides
AssigneeX-Body, Inc.
InventorsYan Chen, Richard W. Wagner, Csaba Pazmany
Life of this patent
Estimating the term…
Abstract
The present invention provides binding polypeptides (e.g., antibodies or fragments thereof) that specifically bind to a target antigen (e.g., a human antigen, e.g., human PDGFRβ) with high affinity. The invention also provides, libraries of binding polypeptides, pharmaceutical compositions, as well as nucleic acids encoding binding polypeptides, recombinant expression vectors and host cells for making such binding polypeptides. Methods of using binding polypeptide of the invention to diagnose and treat disease are also encompassed by the invention.
Claims8
-39. (canceled)
A diverse library of unpaired VH domains, wherein each member of the library binds to human PDGFRβ, and wherein the library is a nucleic acid display library.
A diverse library of stable VH/VL pairs, wherein each member of the library binds to human PDGFRβ, and wherein the library is a nucleic acid display library.
Dependencies are inferred from the claim text.