Multispecific heavy chain antibodies with modified heavy chain constant regions
AssigneeTeneoTwo, Inc.
InventorsKatherine Harris, Ute Schellenberger, Omid Vafa, Nathan Trinklein, Wim van Schooten, Shelley Force Aldred, Duy Pham, Udaya Rangaswamy
Life of this patent
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Abstract
Multispecific, human heavy chain antibodies (e.g., UniAbs™) that have modified heavy chain constant regions that impart advantageous properties are provided. The invention further concerns methods of making such antibodies, compositions, including pharmaceutical compositions, comprising such antibodies, and their use to treat disorders that are characterized by expression of one or more of the binding targets described herein.
Claims21
-60. (canceled)
A bispecific three-chain antibody like molecule that binds to human CD3 and human CD19, comprising:
- (i) a first polypeptide subunit comprising the amino acid sequence of SEQ ID NO:
- 49;
- (ii) a second polypeptide subunit comprising the amino acid sequence of SEQ ID NO:
- 56,
- wherein the first and second polypeptide subunits together form a first binding moiety that binds to human CD3;
- and
- (iii) a third polypeptide subunit that binds to human CD19, comprising the amino acid sequence of SEQ ID NO:
- 67.
A bispecific three-chain antibody like molecule that binds to human CD3 and human CD19, comprising:
- (i) a first polypeptide subunit comprising the amino acid sequence of SEQ ID NO:
- 49;
- (ii) a second polypeptide subunit comprising the amino acid sequence of SEQ ID NO:
- 75,
- wherein the first and second polypeptide subunits together form a first binding moiety that binds to human CD3;
- and
- (iii) a third polypeptide subunit that binds to human CD19, comprising the amino acid sequence of SEQ ID NO:
- 78.
A human, monoclonal IgG4 bispecific antibody comprising:
- (i) a first binding arm that binds to human CD3;
- and
- (ii) a second binding arm that binds to human CD19,
- wherein the first binding arm comprises a first heavy chain comprising the amino acid sequence of SEQ ID NO:
- 56 and a light chain comprising the amino acid sequence of SEQ ID NO:
- 49;
- and
- wherein the second binding arm comprises a monovalent second heavy chain comprising the amino acid sequence of SEQ ID NO:
- 67.
A human, monoclonal IgG4 bispecific antibody comprising:
- (i) a first binding arm that binds to human CD3;
- and
- (ii) a second binding arm that binds to human CD19,
- wherein the first binding arm comprises a first heavy chain comprising the amino acid sequence of SEQ ID NO:
- 75 and a light chain comprising the amino acid sequence of SEQ ID NO:
- 49;
- and
- wherein the second binding arm comprises a monovalent second heavy chain comprising the amino acid sequence of SEQ ID NO:
- 78.
Dependencies are inferred from the claim text.