Antibodies against tim3 and uses thereof

An isolated antibody, which binds to human T-cell immunoglobulin and mucin-domain containing-3 (TIM3), comprising a heavy chain CDR1, CDR2, and CDR3 and a light chain CDR1, CDR2, and CDR3, wherein:

• (a) the heavy chain CDR1, CDR2, and CDR3 comprise SEQ ID NOs:
• 45, 413, and 414, respectively, and the light chain CDR1, CDR2, and CDR3 comprise SEQ ID NOs:
• 64, 66, and 69, respectively;
• (b) the heavy chain CDR1, CDR2, and CDR3 comprise SEQ ID NOs:
• 45, 415, and 416, respectively, and the light chain CDR1, CDR2, and CDR3 comprise SEQ ID NOs:
• 64, 66, and 68, respectively;
• or
• (c) the heavy chain CDR1, CDR2, and CDR3 comprise SEQ ID NOs:
• 45, 415, and 416, respectively, and the light chain CDR1, CDR2, and CDR3 comprise SEQ ID NOs:
• 64, 66, and 419, respectively.

An isolated antibody, which binds to human TIM3, comprising a heavy chain CDR1, CDR2, and CDR3 and a light chain CDR1, CDR2, and CDR3, wherein:

• (a) the heavy chain CDR1 comprises SEQ ID NO:
• 469, the heavy chain CDR2 comprises SEQ ID NO:
• 470, the heavy chain CDR3 comprises SEQ ID NO:
• 471, the light chain CDR1 comprises SEQ ID NO:
• 472, the light chain CDR2 comprises SEQ ID NO:
• 473, and the light chain CDR3 comprises SEQ ID NO:
• 474;
• (b) the heavy chain CDR1 comprises SEQ ID NO:
• 45, the heavy chain CDR2 comprises SEQ ID NO:
• 415, the heavy chain CDR3 comprises SEQ ID NO:
• 416, the light chain CDR1 comprises SEQ ID NO:
• 64, the light chain CDR2 comprises SEQ ID NO:
• 66, and the light chain CDR3 comprises SEQ ID NO:
• 68;
• or
• (c) the heavy chain CDR1 comprises SEQ ID NO:
• 45, the heavy chain CDR2 comprises SEQ ID NO:
• 413, the heavy chain CDR3 comprises SEQ ID NO:
• 414, the light chain CDR1 comprises SEQ ID NO:
• 64, the light chain CDR2 comprises SEQ ID NO:
• 66, and the light chain CDR3 comprises SEQ ID NO:
• 69.

An isolated antibody, which binds to human TIM3, comprising:

• (a1) heavy and light chain sequences comprising SEQ ID NOs:
• 386 (or 387) and 408, respectively;
• (2) heavy and light chain sequences comprising SEQ ID NOs:
• 388 (or 389) and 408, respectively;
• (a3) heavy and light chain sequences comprising SEQ ID NOs:
• 390 (or 391) and 408, respectively;
• (a4) heavy and light chain sequences comprising SEQ ID NOs:
• 392 (or 393) and 408, respectively;
• (b1) heavy and light chain sequences comprising SEQ ID NOs:
• 394 (or 395) and 29, respectively;
• (b2) heavy and light chain sequences comprising SEQ ID NOs:
• 394 (or 395) and 409, respectively;
• (b3) heavy and light chain sequences comprising SEQ ID NOs:
• 396 (or 397) and 29, respectively;
• (b4) heavy and light chain sequences comprising SEQ ID NOs:
• 398 (or 399) and 29, respectively;
• (b5) heavy and light chain sequences comprising SEQ ID NOs:
• 400 (or 401) and 29, respectively;
• (b6) heavy and light chain sequences comprising SEQ ID NOs:
• 402 (or 403) and 29, respectively;
• (b7) heavy and light chain sequences comprising SEQ ID NOs:
• 404 (or 405) and 29, respectively;
• (b8) heavy and light chain sequences comprising SEQ ID NOs:
• 406 (or 407) and 29, respectively;
• (c1) heavy and light chain sequences comprising SEQ ID NOs:
• 451 (or 461) and 453, respectively;
• (c2) heavy and light chain sequences comprising SEQ ID NOs:
• 452 (or 462) and 453, respectively;
• (d1) heavy and light chain sequences comprising SEQ ID NOs:
• 457 (or 465) and 453, respectively;
• or
• (d2) heavy and light chain sequences comprising SEQ ID NOs:
• 458 (or 466) and 453, respectively.