Antibody compositions targeting non-phosphorylated alpha-synuclein aggregates
AssigneeQatar Foundation for Education, Science and Community Development
InventorsOmar El-Agnaf, Nour Khaled Majbour, Nishant Vaikath
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Abstract
The present specification provides a monoclonal antibody that specifically binds aggregated, non-phosphorylated α-synuclein and a hybridoma producing it. Also disclosed are methods of generating antibodies that specifically binds aggregated, non-phosphorylated α-synuclein and uses thereof. Uses of anti-α-synuclein antibody in detection and diagnostic assays, and for prophylaxis or therapy of α-synuclein-associated neurodegenerative diseases, are also disclosed.
Claims20
A monoclonal antibody that specifically binds aggregated, non-phosphorylated α-synuclein comprising a heavy chain variable region (VH) and a light chain variable region (VL), wherein:
- i. the VH comprises heavy chain complementarity determining regions (HCDRs) 1-3 having the amino acid sequences of SEQ ID NOs:7-9, respectively;
- and
- ii. the LH comprises light chain complementarity determining regions (LCDRs) 1-3 having the amino acid sequences of SEQ ID NOs:13-15, respectively.
Dependencies are inferred from the claim text.