Anti-elastin antibodies and methods of use
AssigneeClemson University Research Foundation
InventorsNARENDRA R. VYAVAHARE, CHARLES D. RICE, NASIM NOSOUDI, SAKETH KARAMCHED, VAIDEESH PARASARAM
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Abstract
Antibodies and antigen binding fragments thereof that specifically recognize and bind an epitope of elastin that is exposed and accessible in degraded elastic fiber are described. The antibodies and/or antigen binding fragments can be operably linked to a secondary component, including biologically active agents such as therapeutics and/or imaging agents. Optionally, the antibodies and/or antigen binding fragments thereof can be attached to a surface of a carrier, such as a particle, for specific binding and delivery of the carried agents to degraded elastic fiber.
Claims23
(canceled)
The antibody or antigen binding fragment thereof of claim 4, wherein the antibody is a monoclonal antibody.
The antibody or antigen binding fragment thereof of claim 4, wherein the antibody is a polyclonal antibody.
An antibody or antigen binding fragment thereof comprising one or more of SEQ ID NO:
- 9, SEQ ID NO:
- 11, SEQ ID NO:
- 13, SEQ ID NO:
- 27, SEQ ID NO:
- 29, and SEQ ID NO:
- 31.
Dependencies are inferred from the claim text.