Aggrecan binding immunoglobulins
AssigneesAblynx N.V., Merck Patent GmbH
InventorsSoren Steffensen, Gerald Beste, Guy Hermans, Hans Gühring, Christoph Ladel, Lars Toleikis
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Abstract
The present invention relates to immunoglobulins that specifically bind Aggrecan and more in particular to polypeptides, nucleic acids encoding such polypeptides; to methods for preparing such polypeptides; to compositions and in particular to pharmaceutical compositions that comprise such polypeptides, for prophylactic, therapeutic or diagnostic purposes. In particular, the immunoglobulins of the present invention inhibit the activity of Aggrecan.
Claims90
An immunoglobulin single variable domain (ISV) that specifically binds to Aggrecan.
The ISV according to any of the preceding claims, wherein said ISV is chosen from the group consisting of SEQ ID NO:s 1-19 and 114-118 and ISVs which have more than 80%, such as 90% or 95% sequence identity with any one of SEQ ID NOs:
- 1-19 and 114-118.
The polypeptide according to any one of the preceding claims, wherein said ISVs are directly linked to each other or are linked via a linker.
Dependencies are inferred from the claim text.