Antibodies recognizing tau
AssigneeProthena Biosciences Limited
InventorsRobin BARBOUR, Svetlana ALEXANDER, Mark RENZ, Shuning GAI, Tarlochan S. NIJJAR, Philip James DOLAN, III, Philip PAYNE
Life of this patent
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Abstract
The invention provides antibodies that specifically bind tau. The antibodies inhibit or delay tau-associated pathologies and associated symptomatic deterioration.
Claims103
An isolated monoclonal antibody that competes for binding to human tau with antibody 5G8.
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A method of humanizing a mouse antibody, the method comprising:
- (a) selecting one or more acceptor antibodies;
- (b) identifying the amino acid residues of the mouse antibody to be retained;
- (c) synthesizing a nucleic acid encoding a humanized heavy chain comprising CDRs of the mouse antibody heavy chain and a nucleic acid encoding a humanized light chain comprising CDRs of the mouse antibody light chain;
- and
- (d) expressing the nucleic acids in a host cell to produce a humanized antibody;
- wherein the mouse antibody is 5G8, wherein 5G8 is characterized by a mature heavy chain variable region of SEQ ID NO:
- 7 and a mature light chain variable region of SEQ ID NO:8,
- wherein the mouse antibody is 6A10, wherein 6A10 is characterized by a mature heavy chain variable region of SEQ ID NO:
- 63 and a mature light chain variable region of SEQ ID NO:64,
- wherein the mouse antibody is 8A4, wherein 8A4 is characterized by a mature heavy chain variable region of SEQ ID NO:
- 91 and a mature light chain variable region of SEQ ID NO:92, or
- wherein the mouse antibody is 7G6, wherein 7G6 is characterized by a mature heavy chain variable region of SEQ ID NO:
- 119 and a mature light chain variable region of SEQ ID NO:120.
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An isolated monoclonal antibody that specifically binds to a peptide consisting of residues 199-213 of SEQ ID NO:3.
An isolated monoclonal antibody that specifically binds to a peptide consisting of residues 262-276 of SEQ ID NO:3.
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A method of treating or effecting prophylaxis of a tau-related disease in a subject comprising administering an immunogen comprising a tau peptide of up to 20 contiguous amino acids of SEQ ID NO:3 to which antibody 5G8, 6A10, 8A4 or 7G6 specifically binds, wherein the peptide induces formation of antibodies specifically binding to tau in the subject.
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Dependencies are inferred from the claim text.