Monoclonal antibody or antigen binding fragment thereof that binds to the l protein of the human parainfluenza virus (piv); method and kit for detecting piv
AssigneePontificia Universidad Catolica De Chile
InventorsAlexis Mikes KALERGIS PARRA, Susan Marcela BUENO RAMIREZ
Life of this patent
Estimating the term…
Abstract
Generation of monoclonal antibodies, or fragments thereof, that recognize the human parainfluenza virus (PIV) chimeric protein L, where the monoclonal antibodies or fragments thereof have a heavy chain variable region and a light chain variable region. In addition, a method of diagnosing PIV infection in a biological sample of nasopharyngeal secretion is provided, using the monoclonal antibodies in diagnostic kit format.
Claims10
A monoclonal antibody or an antigen-binding portion thereof that binds to human parainfluenza virus (PIV) protein L for use in detecting the presence and/or localization of the protein, comprising:
- a light chain variable region where its CDR1 (CDRLC1) is defined according to SEQ ID NO:
- 1, its CDR2 (CDRLC2) is defined by SEQ ID NO:
- 2 and its CDR3 (CDRLC3) corresponds to SEQ ID NO:
- 3, and a heavy chain variable region where its CDR1 (CDRHC1) is defined according to SEQ ID NO:
- 4, its CDR2 (CDRHC2) is defined by SEQ ID NO:
- 5 and its CDR3 (CDRHC3) corresponds to SEQ ID NO:
- 6, or
- a light chain variable region where its CDR1 (CDRLC1) is defined according to SEQ ID NO:
- 7, its CDR2 (CDRLC2) is defined by SEQ ID NO:
- 8 and its CDR3 (CDRLC3) corresponds to SEQ ID NO:
- 9, and a heavy chain variable region where its CDR1 (CDRHC1) is defined according to SEQ ID NO:
- 10, its CDR2 (CDRHC2) corresponds to SEQ ID NO:
- 11 and its CDR3 (CDRHC3) corresponds to SEQ ID NO:
- 12,
- wherein said antibody can be used as detection or capture antibody.
(canceled)
Dependencies are inferred from the claim text.