Red blood cell targeted factor viii and method of using the same
AssigneeBayer HealthCare LLC
InventorsAlan Brooks, Richard Feldman, Jian-Ming GU, Shaun Lippow, Shujun Yuan, Peter Bringmann
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Abstract
Targeted Factor VIII molecules comprising a Factor VIII linked with at least one domain that specifically binds to a membrane protein on a red blood cell is provided. The disclosed targeted coagulation factors prolong their duration of action and thus, are an improvement for the treatment of hematological diseases such as hemophilia A.
Claims8
1-21. (canceled)
A recombinant fusion protein comprising a protein wherein extension of circulating half-life would be beneficial to a patient, and at least one binding domain that specifically binds to a membrane protein on a red blood cell.
Dependencies are inferred from the claim text.