Type 1 interferon neutralizing fc-fusion protein and use thereof
AssigneesSeoul National University R&Db Foundation, Logone Bio Convergence Research Foundation
InventorsYoung Kee SHIN, Sae Hyung LEE, Sung Su KIM
Life of this patent
Estimating the term…
Abstract
The present invention relates to a type 1 interferon neutralizing FC-fusion protein and a use thereof and, more specifically, to: a dimer-type polypeptide to which a monomer comprising an interferon receptor fragment or an antibody Fc fragment is bound; a preparation method there for; and a pharmaceutical composition comprising same. The type 1 interferon neutralizing FC-fusion protein of the present invention blocks binding between type 1 interferon and an interferon receptor, and has an excellent ability of inhibiting the signaling and biological activities of interferon, thereby enabling diseases mediated by a type 1 interferon to be effectively treated.
Claims14
A dimeric polypeptide in which a monomer comprising an interferon receptor fragment or an antibody Fc fragment is bound,
- wherein the monomer is a polypeptide selected from the group consisting of (i), (ii) and (iii):
- (i) a monomer comprising an interferon receptor 1 (IFNAR1) fragment and an antibody Fc fragment;
- (ii) a monomer comprising an interferon receptor 2 (IFNAR2) fragment and an antibody Fc fragment;
- and
- (iii) an antibody Fc fragment.
Dependencies are inferred from the claim text.